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ACE Report #8149
Ace Report Cover Osteoarthritis

Hyaluronate vs distention vs placebo for Knee OA: no difference in osteoarthritis

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial.

. 2008 ;():.

Contributing Authors: C Lundsgaard N Dufour E Fallentin P Winkel C Gluud

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251 patients with symptomatic knee osteoarthritis, who did not respond to conservative or pharmaceutical treatment, were randomized to receive either hyaluronate, 20 mL saline (distention) or 2 mL saline placebo as an intra-articular injection. The purpose of this study was to compare changes in pain and function of the affected knee between the treatment groups. Results indicated that over a 26 w...

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