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ACE Report #8140
Ace Report Cover Osteoarthritis

Small effect of hyaluronic acid for pain relief in treatment of knee osteoarthrits

Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis

JAMA. 2003 Dec 17;290(23):3115-21

Contributing Authors: GH Lo M LaValley T McAlindon DT Felson

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A total of 22 randomized controlled trials were included in the meta-analysis investigating the effect of hyaluronic acid on pain in the treatment of knee osteoarthritis. Data was sampled from a total of 2949 patients across all trials. The results demonstrated a small, but significant, effect size when intra-articular hyaluronic acid was compared to placebo for pain severity. An analysis of only ...

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