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Meta-analysis
ACE Report #8129
Ace Report Cover Osteoarthritis

Limited efficacy of intra-articular hyaluronic acid in treatment of knee OA


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis

CMAJ. 2005 Apr 12;172(8):1039-43

Contributing Authors: J Arrich F Piribauer P Mad D Schmid K Klaushofer M Müllner

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Synopsis

22 randomized controlled trials were included in this meta-analysis investigating the efficacy of intra-articular hyaluronic acid injections in the treatment of knee osteoarthritis. Data was extracted from identified studies for outcomes of pain at rest, pain during activity, and functional measures, and pooled at 4 different time intervals: 2-6 weeks, 10-14 weeks, 22-30 weeks, and 44-60 weeks. An...

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