Zoledronic acid has no continued benefit beyond 6 years for osteoporosis
The Effect of 6 versus 9 Years of Zoledronic Acid Treatment in Osteoporosis: A Randomized Second Extension to the HORIZON-Pivotal Fracture Trial (PFT)J Bone Miner Res. 2015 May;30(5):934-44.
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One hundred and ninety patients were randomized to receive either continued zolderonic acid (ZOL) treatment or were switched to a placebo after six years of ZOL treatment for osteoporosis. Patients received treatment for an additional 3 years to determine continued efficacy and safety of ZOL. Results found that there was no significant benefit to continued ZOL treatment. Additionally, there was a ...
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