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Methylnaltrexone reduces morphine side effects after orthopedic surgery
July 2016
Methylnaltrexone reduces morphine side effects after orthopedic surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
The Effect of Methylnaltrexone on the Side Effects of Intrathecal Morphine after Orthopedic Surgery under Spinal Anesthesia
Pain Pract. 2015 Apr;15(4):348-54Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
72 patients scheduled to undergo orthopaedic surgery (femoral fracture, tibial fracture, patellar fracture, ankle fracture) under spinal anesthesia were randomized to be administered 12 mg methylnaltrexone or 12 mg of normal saline placebo subcutaneously following the administration of intrathecal morphine. The purpose of this study was to examine the remedial effects of methylnaltrexone on the po...
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