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Meta-analysis
ACE Report #7743

No clinical change for PCL sacrifice vs retention in TKA


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Similar outcome after retention or sacrifice of the posterior cruciate ligament in total knee arthroplasty

Acta Orthop. 2015 Apr;86(2):195-201.

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Synopsis

Posterior cruciate ligament (PCL) retention or sacrifice was compared in 20 studies. A total of 2347 knees from 1877 patients were considered. Statistically significant differences in postoperative flexion and KSS scores were observed in favor of sacrifice, however these differences did not reach clinical significance. Due to the lack of patient-important differences between these treatments neither can be recommended over the other.

Publication Funding Details +
Funding:
Non-Industry funded
Sponsor:
Sanquin Blood Bank, the Netherlands; Dutch Rheumatology Association
Conflicts:
None disclosed

Risk of Bias

10/10

Reporting Criteria

18/20

Fragility Index

N/A

Were the search methods used to find evidence (original research) on the primary question or questions stated?

Was the search for evidence reasonably comprehensive?

Were the criteria used for deciding which studies to include in the overview reported?

Was the bias in the selection of studies avoided?

Were the criteria used for assessing the validity of the included studies reported?

Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?

Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?

Were the findings of the relevant studies combined appropriately relative to the primary question that the overview addresses?

Were the conclusions made by the author or authors supported by the data and or analysis reported in the overview?

How would you rate the scientific quality of this evidence?

Yes = 1

Uncertain = 0.5

Not Relevant = 0

No = 0

The Reporting Criteria Assessment evaluates the transparency with which authors report the methodological and trial characteristics of the trial within the publication. The assessment is divided into five categories which are presented below.

4/4

Introduction

3/4

Accessing Data

4/4

Analysing Data

4/4

Results

3/4

Discussion

Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65

The Fragility Index is a tool that aids in the interpretation of significant findings, providing a measure of strength for a result. The Fragility Index represents the number of consecutive events that need to be added to a dichotomous outcome to make the finding no longer significant. A small number represents a weaker finding and a large number represents a stronger finding.

Why was this study needed now?

Retention of the posterior cruciate ligament (PCL) is a point of disagreement in total knee arthroplasty (TKA). The PCL has been found to provide normal proprioception and kinesthesia, as well as natural knee function. However, if the PCL is not balanced appropriately, many complications can arise. A previous meta-analysis was unable to determine if PCL retention or sacrifice provides better clinical outcomes. Since the publication of this meta-analysis a number of new trials have been completed. This meta-analysis will provide an update of previous work, giving an up to date view on the topic.

What was the principal research question?

Are there differences in functional, clinical, and radiological outcomes at a minimum of one year follow-up when comparing PCL-retaining and PCL-sacrificing total knee arthroplasty?

Study Characteristics -
Data Source:
An online search of the following databases was performed from inception to May 19, 2014: Medline, Cochrane Central Register of Controlled Trials, Embase, Web of Science, CINAHL, Academic Search Premier, Current Contents Connect, and ScienceDirect. Additional searches were performed using the bibliographies of the articles to track citations.
Index Terms:
Refer to Table 1 in supplementary data (http://www.actaorthop.org/sup_files/7534.pdf)
Study Selection:
Inclusion criteria required studies to be primary TKA comparing PCL retention to PCL sacrifice, TKA had to be for osteoarthritis treatment, minimum of one year follow-up, and studies had to be RCTs or quasi-RCTs. Quasi-RCTs were defined as studies using date of birth, patient identification number, or alternating sequences for randomization. Studies were independently selected by two reviewers, consensus was used to solve disagreements, and a third reviewer was used if a consensus could not be reached. 20 studies with 1877 patients were included in this meta-analysis.
Data Extraction:
Not reported
Data Synthesis:
Data pooling was performed using Review Manager. Continuous data were reported as mean differences, and dichotomous as number of events. Standard deviations were used, and when unavailable, confidence intervals were used. Heterogeneity was assessed using the I^2 statistic and the Q statistic (p<0.05). A random effects model was used for all analyses.

What were the important findings?

  • 5 studies had low risk of bias, 5 studies had high risk of bias, and 10 studies had an unclear risk of bias
  • There was a mean difference in postoperative flexion angle of 2.11 degrees (12 studies: [95% CI 0.23, 3.98]; p=0.03; I^2=29%)
  • Knee Society functional score had a statistically significant increase of 2.36 points when PCL was sacrificed (9 studies: [95% CI 0.41, 4.3]; p=0.02; I^2=0.0%)
  • WOMAC score had a non-significant difference between PCL sacrifice and retention (5 studies: [95% CI -0.35, 1.79]; p=0.19)
  • No significant differences were found in the KSS pain, clinical or overall score, HSS score, SF-12, and radiolucent lines (p>0.05)

What should I remember most?

There were no clinically relevant differences in clinical and functional outcomes between posterior cruciate ligament sacrifice and retention in TKA.

How will this affect the care of my patients?

No clinical difference was found between PCL sacrifice and retention in terms of functional and clinical scores. Results should be interpreted with caution, as many reports had either high risk of bias or an unclear risk of bias. Future studies should focus on additional outcomes, more preoperative information, cost effectiveness, and larger populations.

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