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Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake
March 2015
Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.
Am J Clin Nutr. 2014 Dec;100(6):1578-86.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
2919 elderly hyperhomocysteinemic patients at risk for osteoporotic fractures were randomized to receive daily oral supplements containing 500 mg vitamin B-12, 400 mg folic acid and 600 IU of vitamin D3 or a placebo supplement containing only vitamin D3. The purpose of this study was to investigate whether the intake of vitamin B-12 and folic acid impacted the time to first osteoporotic fracture a...
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