Opioid use effective in reducing pain and improving function in OA patients
Efficacy and safety of opioids for osteoarthritis: a meta-analysis of randomized controlled trialsOsteoarthritis Cartilage. 2007 Aug;15(8):957-65. Epub 2007 Mar 29
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This meta-analysis identified 22 randomized controlled trials that compared the use of opioids to placebo or non-opioid analgesics with respect to the reduction of pain and improved function in patients with osteoarthritis. Of these studies, 18 were randomized placebo-controlled trials (the other 4 studies compared opioids to NSAID's or paracetamol, and did not provide enough robust data). Of the ...
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