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Use of thiazolidinediones increases the risk of fracture in women
January 2015
Use of thiazolidinediones increases the risk of fracture in women
Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A
Risk of fracture with thiazolidinediones: an updated meta-analysis of randomized clinical trials
Bone. 2014 Nov;68:115-23Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
27 randomized controlled trials were included in this meta-analysis. The purpose of this study was to determine if the use of thiazolidinediones (TZDs) was associated with the risk of fracture and if it had any effects on bone mineral density. Pooled findings demonstrated that the use of TZDs significantly increased the risk of fracture, particularly in women.
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