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ACE Report #6705
Ace Report Cover General Orthopaedics

Extended-release metoprolol in the prevention of CV complications in non-cardiac surgery

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial

Lancet. 2008 May 31;371(9627):1839-47. doi: 10.1016/S0140-6736(08)60601-7. Epub 2008 May 12.

Contributing Authors: POISE Study Group PJ Devereaux H Yang S Yusuf G Guyatt K Leslie JC Villar D Xavier S Chrolavicius L Greenspan J Pogue P Pais L Liu S Xu G Málaga A Avezum M Chan VM Montori M Jacka P Choi

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9298 patients with, or at risk of, atherosclerotic disease and undergoing non-cardiac surgery, were randomized to receive perioperative administration of either extended-release metoprolol or a placebo equivalent. The purpose of this study was to compare these two groups with respect to rates of cardiovascular complications over a period of 30 postoperative days. Results indicated that, although t...

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