EFORT: Intraossesous regional vancomycin effective for antibiotic tissue levels in TKA
Low-dose intraosseous regional vancomycin prophylaxis in TKA: A randomized controlled trial
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30 patients undergoing total knee arthroplasty were randomized to one of three groups for antibiotic prophylaxis: 1g intravenous (IV) vancomycin, 250mg intraosseous regional administration (IORA) vancomycin, and 500mg IORA vancomycin. Subcutaneous fat and femoral bone samples were collected throughout the procedure and assessed for antibiotic concentration. The results demonstrated significantly h...
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