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RCT
ACE Report #59
Ace Report Cover Foot & Ankle

rhPDGF-BB (Augment) is a safe alternative to autologous graft in foot and ankle fusion


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Prospective, Randomized, Multi-Center Feasibility Trial of rhPDGF-BB Versus Autologous Bone Graft in a Foot and Ankle Fusion Model

Foot Ankle Int. 2011 Apr;32(4):344-54.

Contributing Authors: CW Digiovanni J Baumhauer SS Lin WS Berberian AS Flemister MJ Enna P Evangelista J Newman

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Synopsis

20 patients requiring hindfoot fusion were randomized to receive either a biosynthetic bone graft substitute (Augment Bone Graft, a recombinant form of platelet-derived growth factor (rhPDGF-BB)) or an autologous bone graft (ABG), in order to compare safety and efficacy between the two graft types. The results of this study suggest the biosynthetic bone graft is a safe and efficacious alternative ...

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