Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients
The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.Osteoarthritis Cartilage. 2013 Sep;21(9):1400-8
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100 patients enrolled in this study to determine the effects of specific nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis of the knee. High and low doses of celecoxib, diclofenac and ibuprofen were administered for 2 weeks prior to TKA operation. The results taken just before the operation suggest that Interleukin-6 (IL-6), tumor necrosis factor-alpha and vascular endothelia...
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