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ACE Report #5588
Ace Report Cover Osteoarthritis

Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.

Osteoarthritis Cartilage. 2013 Sep;21(9):1400-8

Contributing Authors: L Gallelli O Galasso D Falcone S Southworth M Greco V Ventura P Romualdi A Corigliano R Terracciano R Savino E Gulletta G Gasparini G De Sarro

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Synopsis

100 patients enrolled in this study to determine the effects of specific nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis of the knee. High and low doses of celecoxib, diclofenac and ibuprofen were administered for 2 weeks prior to TKA operation. The results taken just before the operation suggest that Interleukin-6 (IL-6), tumor necrosis factor-alpha and vascular endothelia...

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