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RCT
ACE Report #5299
Ace Report Cover Osteoarthritis

Ankle OA: 3 weekly injections of 1 mL hyaluronic acid reduces ankle joint pain


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Intra-articular sodium hyaluronate injections in the osteoarthritic ankle joint: effects, safety and dose dependency

Foot Ankle Surg. 2010 Dec;16(4):159-63. doi: 10.1016/j.fas.2009.10.003. Epub 2009 Nov 8

Contributing Authors: AG Witteveen IN Sierevelt L Blankevoort GM Kerkhoffs CN van Dijk

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Synopsis

26 patients with ankle joint osteoarthritis were randomized to receive either single injections of high molecular weight hyaluronic acid (HA) (Orthovisc) at 1 mL, 2 mL, or 3 mL dosages, or 3 weekly injections of HA at a 1 mL dosage, to determine the effectiveness, safety, and dose dependency of the injections. Following 27 weeks of evaluations, results indicated that the effectiveness of hyaluroni...

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