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Meta-analysis
ACE Report #5215
Ace Report Cover Spine

Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:2
Journal Level of Evidence:N/A

Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion: A Meta-analysis of Individual-Participant Data

Ann Intern Med. 2013 Jun 18;158(12):877-89. doi: 10.7326/0003-4819-158-12-201306180-00005

Contributing Authors: MC Simmonds JV Brown MK Heirs JP Higgins RJ Mannion MA Rodgers LA Stewart

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Synopsis

This review/meta-analysis comprised of individual participant data from 11 Medtronic trials and 1 randomized trial, and aggregate data extracted from 35 observational studies, to investigate the efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) compared to iliac crest bone grafts in spinal fusion. An analysis of results revealed that fusion rates were higher with rhBMP-2, but di...

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