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Volume:2 Issue:7 Number:601 ISSN#:2563-5476
RCT
ACE Report #5081
Ace Report Cover Osteoarthritis

Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab


How to Cite

OrthoEvidence. Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab. ACE Report. 2013;2(7):601. Available from: https://myorthoevidence.com/AceReport/Report/5081

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial

Lancet. 2013 May 4;381(9877):1541-50. doi: 10.1016/S0140-6736(13)60250-0. Epub 2013 Mar 18

Contributing Authors: C Gabay P Emery R van Vollenhoven A Dikranian R Alten K Pavelka M Klearman D Musselman S Agarwal J Green A Kavanaugh ADACTA Study Investigators

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Synopsis

326 patients with severe rheumatoid arthritis, with whom methotrexate was deemed inappropriate, were randomized to receive tocilizumab intravenously every 4 weeks plus a placebo subcutaneously every 2 weeks for 24 weeks or adalimumab subcutaneously every 2 weeks plus a placebo intravenously every 4 weeks for 24 weeks, in order to compare the safety and efficacy between the two drugs. After the 24 ...

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