ISAKOS: MACI Implant superior compared to Microfracture for articular cartilage defects
Matrix-Induced Autologous Chondrocyte Implant vs. Microfracture: Prospective, Randomized Trial in European Patients, 2-Year Follow Up
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To investigate the use of matrix-induced autologous implant (MACI) in treatment of symptomatic articular cartilage defects of the knee, the phase 3 of the SUMMIT trial randomised 144 patients to either matrix-induced autologous implant (MACI) or microfracture group. At a 2 year follow up, MACI group demonstrated significantly better pain and functional outcomes with no adverse events.
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