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ACE Report #4959
Ace Report Cover General Orthopaedics

ISAKOS: MACI Implant superior compared to Microfracture for articular cartilage defects

Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Matrix-Induced Autologous Chondrocyte Implant vs. Microfracture: Prospective, Randomized Trial in European Patients, 2-Year Follow Up

Contributing Authors: M Brittberg J Caron P Emans S Kili Bezauidenhoudt B-J Sanson Levine AJ Price

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


To investigate the use of matrix-induced autologous implant (MACI) in treatment of symptomatic articular cartilage defects of the knee, the phase 3 of the SUMMIT trial randomised 144 patients to either matrix-induced autologous implant (MACI) or microfracture group. At a 2 year follow up, MACI group demonstrated significantly better pain and functional outcomes with no adverse events.

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