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ACE Report #4791
Ace Report Cover Pediatric Orthopaedics

Botulinum A toxin improves upper extremity function in children with cerebral palsy

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Upper extremity spasticity in children with cerebral palsy: a randomized, double-blind, placebo-controlled study of the short-term outcomes of treatment with botulinum A toxin

J Hand Surg Am. 2013 Mar;38(3):435-46.e1. doi: 10.1016/j.jhsa.2012.12.019

Contributing Authors: LA Koman BP Smith R Williams R Richardson M Naughton L Griffin P Evans

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This study randomized 73 children suffering from cerebral palsy with varying levels of function to assess the safety and efficacy of upper extremity injections of BoNT-A by comparing it to a placebo. The assessment at 26 weeks revealed that BoNT-A injections led to significant short-term improvements in upper extremity function when compared to placebo.

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