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Volume:2 Issue:3 Number:30 ISSN#:2563-5476
RCT
ACE Report #4744
Ace Report Cover Spine

The role of alendronate in osteoporosis patients undergoing PLIF


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial

J Neurosurg Spine. 2011 Apr;14(4):500-7. doi: 10.3171/2010.11.SPINE10245. Epub 2011 Jan 28

Contributing Authors: K Nagahama M Kanayama D Togawa T Hashimoto A Minami

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Synopsis

40 osteoporosis patients undergoing single-level posterior lumbar interbody fusion were randomized to receive alendronate or vitamin D (alfacalcidol) to determine the impact of bisphosphonates on the spinal fusion recovery process. Following clinical, radiographic, and biochemical evaluations over a 12 month period, the results indicated that greater solid fusion, less cage subsidence, and no vert...

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