The role of alendronate in osteoporosis patients undergoing PLIF
Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trialJ Neurosurg Spine. 2011 Apr;14(4):500-7. doi: 10.3171/2010.11.SPINE10245. Epub 2011 Jan 28
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40 osteoporosis patients undergoing single-level posterior lumbar interbody fusion were randomized to receive alendronate or vitamin D (alfacalcidol) to determine the impact of bisphosphonates on the spinal fusion recovery process. Following clinical, radiographic, and biochemical evaluations over a 12 month period, the results indicated that greater solid fusion, less cage subsidence, and no vert...
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