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Zaltoprofen is noninferior to diclofenac for the treatment of knee OA
March 2014
Zaltoprofen is noninferior to diclofenac for the treatment of knee OA
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Zaltoprofen, a noninferior alternative to diclofenac for the treatment of primary knee osteoarthritis -- a comparative evaluation of efficacy and safety in a 4-week, multicentric, randomized, double-blind, double-dummy trial
Expert Opin Pharmacother. 2011 May;12(7):1007-15. doi: 10.1517/14656566.2011.566867. Epub 2011 Apr 7Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
This study evaluated whether zaltoprofen was as a noninferior alternative (in regards to safety and efficacy) to diclofenac for the treatment of knee osteoarthritis (OA). 213 patients were randomized to either zaltoprofen (80 mg t.i.d.) or diclofenac (50 mg t.i.d.) and were assessed after 4 weeks. Results indicated that both groups experienced significant (but comparable) improvement in pain inten...
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