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Bisphosphonates prevent periprosthetic bone loss following arthroplasty over the mid-term
September 2013
Bisphosphonates prevent periprosthetic bone loss following arthroplasty over the mid-term
Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A
Bisphosphonates for periprosthetic bone loss after joint arthroplasty: a meta-analysis of 14 randomized controlled trials
Osteoporos Int. 2012 Jun;23(6):1823-34. doi: 10.1007/s00198-011-1797-5. Epub 2011 Sep 20Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
A meta-analysis consisting of 14 RCTs (671 patients) was conducted to determine the efficacy of bisphosphonates (BPs) on maintaining periprosthetic bone mass after joint arthroplasty, as well as their potential influential factors and adverse events. After 72 months of follow up, bisphosphonates demonstrated significant short-term and middle-term efficacy in bone loss prevention, with second and t...
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