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RCT
ACE Report #3780
Ace Report Cover Arthroplasty

TKA: Wound infiltration with DepoFoam bupivacaine is an effective postoperative analgesia


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty

Knee. 2012 Oct;19(5):530-6. doi: 10.1016/j.knee.2011.12.004. Epub 2012 Jan 28

Contributing Authors: K Bramlett E Onel ER Viscusi K Jones

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Synopsis

144 patients who were undergoing primary unilateral total knee arthroplasty (TKA) were randomized to receive wound infiltration with DepoFoam bupivacaine (133 mg, 266 mg, 399 mg or 532 mg) or bupivacaine HCl with epinephrine. Over 5 days, the DepoFoam bupivacaine groups had significantly lower pain scores at rest than the bupivacaine HCl group at several time periods. On day 5, the cumulative pain...

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