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Volume:3 Issue:2 Number:11 ISSN#:2563-5476
RCT
ACE Report #3777
Ace Report Cover Trauma

Discontinuing alendronate after 5 years of treatment, does it affect fracture risk?


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effects of Continuing or Stopping Alendronate After 5 Years of Treatment The Fracture Intervention Trial Long-term Extension (FLEX): A Randomized Trial

JAMA. 2006 Dec 27;296(24):2927-38.

Contributing Authors: Dennis M Black Ann V Schwartz Kristine E Ensrud Jane A Cauley Silvina Levis Sara A Quandt Suzanne Satterfield Robert B Wallace Douglas C Bauer Lisa Palermo Lois E Wehren Antonio Lombardi Arthur C Santora Steven R Cummings

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Synopsis

1099 postmenopausal women randomized to receive alendronate in FIT and underwent 5 years of prior alendronate treatment were further randomized to receive 5 mg or 10 mg of alendronate, or a placebo for 5 years. The results of the study revealed that women who had discontinued alendronate treatment after 5 years experienced a moderate decline in bone mineral density and a moderate rise in biochemic...

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