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Volume:1 Issue:3 Number:263 ISSN#:2563-5476
RCT
ACE Report #364
Ace Report Cover General Orthopaedics

Hemoglobin based oxygen carrier-201: A safe and effective way to save packed blood


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

HBOC-201 as an Alternative to Blood Transfusion: Efficacy and Safety Evaluation in a Multicenter Phase III Trial in Elective Orthopedic Surgery

J Trauma. 2008 Jun;64(6):1484-97.

Contributing Authors: Jonathan S Jahr Colin Mackenzie L Bruce Pearce Arkadiy Pitman A Gerson Greenburg

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Synopsis

688 patients, older 18 years, undergoing non-emergency orthopedic surgery were randomized to treatment with hemoglobin based oxygen carrier-201 (HBOC-201) or packed RBC at the first transfusion decision. After 6 weeks, HBOC-201 was found to be a suitable alternative to packed red blood cell transfusion for patients younger than 80 years with moderate clinical need, undergoing elective orthopedic ...

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