Alendronate is superior to alfacalcidol in preventing glucocorticoid-induced bone loss
Alendronate or Alfacalcidol in Glucocorticoid-Induced OsteoporosisN Engl J Med. 2006 Aug 17;355(7):675-84
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201 patients with a rheumatic disease who were starting daily doses of glucocorticoids were randomized to receive 10 mg of alendronate and a placebo capsule of alfacalcidol daily or 1 ug of alfacalcidol and a placebo tablet of alendronate daily. At 18 months, the lumbar spine bone mineral density of patients who received alendronate had increased significantly more than that of the patients who re...
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