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Volume:1 Issue:8 Number:530 ISSN#:2563-5476
RCT
ACE Report #3604
Ace Report Cover General Orthopaedics

Alendronate is superior to alfacalcidol in preventing glucocorticoid-induced bone loss


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Alendronate or Alfacalcidol in Glucocorticoid-Induced Osteoporosis

N Engl J Med. 2006 Aug 17;355(7):675-84

Contributing Authors: RN de Nijs JW Jacobs WF Lems RF Laan A Algra AM Huisman E Buskens CE de Laet AC Oostveen PP Geusens GA Bruyn BA Dijkmans JW Bijlsma STOP Investigators

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Synopsis

201 patients with a rheumatic disease who were starting daily doses of glucocorticoids were randomized to receive 10 mg of alendronate and a placebo capsule of alfacalcidol daily or 1 ug of alfacalcidol and a placebo tablet of alendronate daily. At 18 months, the lumbar spine bone mineral density of patients who received alendronate had increased significantly more than that of the patients who re...

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