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RCT
ACE Report #31
Ace Report Cover Osteoarthritis

Muscle strength training plus glucosamine alters cartilage turnover in OA patients


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training

Osteoarthritis Cartilage. 2010 Jan;18(1):34-40. Epub 2009 Jul 15

Contributing Authors: SG Petersen T Saxne D Heinegard M Hansen L Holm S Koskinen C Stordal H Christensenshort P Aagaard M Kjaer

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Synopsis

36 adult patients (16M 20F) with bilateral tibiofemoral knee osteoarthritis, enrolled in a strength training program for both legs of 12 week duration, were randomized to receive glucosamine, ibuprofen, or placebo. 12 weeks of muscle strength training, in combination with glucosamine, reduced the serum cartilage oligomeric matrix protein level in patients with bilateral tibiofemoral knee osteoarth...

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