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RCT
ACE Report #2873
Ace Report Cover Trauma

rhBMP-7 results in higher union rates compared to PRP in treatment of long bone non-unions


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions - A prospective randomised clinical study on 120 patients

Injury. 2008 Dec;39(12):1391-402. Epub 2008 Nov 22

Contributing Authors: GM Calori L Tagliabue L Gala M d\'Imporzano G Peretti W Albisetti

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Synopsis

120 patients with persistent long bone fracture non-unions were randomized to either receive recombinant bone morphogenic protein (rhBMP-7) or platelet-rich plasma (PRP). The results at a mean follow-up of 12 months indicated that rhBMP-7 had superior clinical and radiographic effectiveness compared to platelet-rich plasma. RhBMP-7 resulted in a greater percentage of non-unions that achieved clini...

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