OTA 2022: PAIN Trial - Effect of NSAIDs and Pregabalin on Non-Union in Trauma Patients
Do NSAIDs Increase the Risk of Non-Union? Results of the PAIN Study, A Three-Arm, Multicenter, Double Blind, Randomized Control Trial
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CONFERENCE ACE REPORTS
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Four hundred and thirty-five trauma patients were randomized in this non-inferiority trial to receive standard pain management plus an NSAID (n=141), pregabalin, (n=146) or placebo (n=148). Outcomes of interest included non-union between 6-12 months post-surgery, opioid utilization in the first 48 hours, and pain scores at 3 months. Results revealed NSAIDs and pregabalin to be non-inferior to plac...
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