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OTA 2022: PAIN Trial - Effect of NSAIDs and Pregabalin on Non-Union in Trauma Patients
October 2022
OTA 2022: PAIN Trial - Effect of NSAIDs and Pregabalin on Non-Union in Trauma Patients
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A
Do NSAIDs Increase the Risk of Non-Union? Results of the PAIN Study, A Three-Arm, Multicenter, Double Blind, Randomized Control Trial
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CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Synopsis
Four hundred and thirty-five trauma patients were randomized in this non-inferiority trial to receive standard pain management plus an NSAID (n=141), pregabalin, (n=146) or placebo (n=148). Outcomes of interest included non-union between 6-12 months post-surgery, opioid utilization in the first 48 hours, and pain scores at 3 months. Results revealed NSAIDs and pregabalin to be non-inferior to plac...
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