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General Orthopaedics

No Clinical Benefit of LY-CoV555 Antibodies Plus Remdesivir in Hospitalized COVID-19 Patients

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April 2021
General Orthopaedics

No Clinical Benefit of LY-CoV555 Antibodies Plus Remdesivir in Hospitalized COVID-19 Patients

Vol: 20| Issue: 1| Number:4| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19

N Engl J Med. 2021 Mar 11;384(10): 905-914.

Contributing Authors:
Group ACTIV-3/TICO LY-CoV555 Study JD Lundgren B Grund CE Barkauskas TL Holland RL Gottlieb U Sandkovsky SM Brown KU Knowlton WH Self DC Files MK Jain T Benfield ME Bowdish BG Leshnower JV Baker JU Jensen EM Gardner AA Ginde ES Harris IS Johansen N Markowitz MA Matthay L √òstergaard CC Chang VJ Davey A Goodman ES Higgs DD Murray TA Murray R Paredes MKB Parmar AN Phillips C Reilly S Sharma RL Dewar M Teitelbaum D Wentworth H Cao P Klekotka AG Babiker AC Gelijns VL Kan MN Polizzotto BT Thompson HC Lane JD Neaton

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Synopsis

Three hundred and fourteen hospitalized patients with COVID-19 were randomized to receive a single intravenous infusion of LY-CoV555 antibody therapy (n=163) or placebo (n=151) for the improvement of recovery and reduction of adverse events. The primary outcomes of interest was sustained recovery (discharged home and remaining at home for at lest 14 days) and a composite safety outcome of death, s...

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