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No Clinical Benefit of 12 Weeks of Daily Oral Colchicine vs Placebo for Hand Osteoarthritis
April 2021
No Clinical Benefit of 12 Weeks of Daily Oral Colchicine vs Placebo for Hand Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Colchicine is not effective for reducing osteoarthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH)
Osteoarthritis Cartilage. 2021 Feb;29(2): 208-214.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Sixty-four elderly patients diagnosed with hand osteoarthritis (OA) were randomized to receive 1 mg/day of colchicine (n=32) tablets or placebo tablets (n=32) for 12 weeks. The primary outcome of interest included hand pain measured using the Visual Analogue Scale (VAS), assessed at 6, 12 and 16 weeks follow-up. Secondary outcomes of interest included hand grip strength, tender and swollen joint (...
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