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Long-Term Maintenance of Clodronate Effective in Reducing Pain and Improving Function in Knee OA
October 2020
Long-Term Maintenance of Clodronate Effective in Reducing Pain and Improving Function in Knee OA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study.
Drugs in R&D.2020 Mar;20(1):39-45Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Seventy-four patients with chronic knee pain from knee osteoarthritis, who received intramuscular clodronate 200 mg/day for 15 days, were randomized into receiving clodronate once/week for the next 11.5 months or once/week for the next 2.5 months. The primary outcome of interest was pain on a Visual Analogue Scale (VAS). Secondary outcomes of interest included the Western Ontario and McMaster Univ...
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