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Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control
February 2019
Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control
Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:N/A
Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: A prospective randomized clinical trial
Thromb Res. 2018 Nov;171:68-73. doi: 10.1016/j.thromres.2018.09.054Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
118 patients scheduled for total knee arthroplasty without a tourniquet and intravenous tranexamic acid administration prior to incision were randomized to three postoperative doses of either 2g oral tranexamic acid or 1g intravenous tranexamic acid. Patients were assessed primarily for drop in hemoglobin and hematocrit levels, as well as for secondary outcomes of total blood loss, hidden blood lo...
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