Nonsignificant differences in outcome at follow-up between low and high-MW HA for knee OA
Comparison of two hyaluronan drugs in patients with advanced osteoarthritis of the knee. A prospective, randomized, double-blind study with long term follow-upClin Exp Rheumatol. 2005 Mar-Apr;23(2):213-8
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92 patients with Kellgren-Lawrence grade III knee osteoarthritis were randomized to three weekly intraarticular injections of either low molecular weight hyaluronic acid (LMW HA; Orthovisc, Anika Therapeutics) or high molecular weight hyaluronic acid (HMW HA; Hylan G-F20, Synvisc, Wyeth). Patients were assessed for improvement from baseline in pain at rest, pain during activity, pain during stair ...
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