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RCT
ACE Report #10699
Ace Report Cover Osteoarthritis

Nonsignificant differences in outcome at follow-up between low and high-MW HA for knee OA


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Comparison of two hyaluronan drugs in patients with advanced osteoarthritis of the knee. A prospective, randomized, double-blind study with long term follow-up

Clin Exp Rheumatol. 2005 Mar-Apr;23(2):213-8

Contributing Authors: A Sen B Unver V Karatosun Z Gocen

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Synopsis

92 patients with Kellgren-Lawrence grade III knee osteoarthritis were randomized to three weekly intraarticular injections of either low molecular weight hyaluronic acid (LMW HA; Orthovisc, Anika Therapeutics) or high molecular weight hyaluronic acid (HMW HA; Hylan G-F20, Synvisc, Wyeth). Patients were assessed for improvement from baseline in pain at rest, pain during activity, pain during stair ...

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