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RCT
ACE Report #10514
Ace Report Cover Osteoarthritis

Noninferior improvement in function over 24 weeks with Structovial HA vs Hylan G-F 20 HA for knee OA


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Comparative efficacy and safety of two different molecular weight (MW) hyaluronans F60027 and Hylan G-F20 in symptomatic osteoarthritis of the knee (KOA). Results of a non inferiority, prospective, randomized, controlled trial.

Clin Exp Rheumatol. 2011 May-Jun;29(3):527-35

Contributing Authors: M Zaim T Trc F Berenbaum E Maheu T Appelboom S Jeka K Maasalu

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Synopsis

279 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to three weekly intraarticular injections of either F60027 sodium hyaluronate (Structovial; Pierre Fabre) or Hylan G-F20 (Synvisc). The primary purpose of this study was to examine if F60027 was noninferior to Hylan G-F20 for functional improvement over 24-week follow-up. Mean improvement in Lequesne Index score f...

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