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Volume:1 Issue:7 Number:63 ISSN#:2563-5476
RCT
ACE Report #105
Ace Report Cover Arthroplasty

Bisphosphonates in revision THA ineffective in altering pseudomembrane cytokine expression


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effect of alendronate on pseudomembrane cytokine expression in patients with aseptic osteolysis

J Arthroplasty. 2010 Sep;25(6):958-63

Contributing Authors: G Holt J Reilly RM Meek

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Synopsis

10 patients, scheduled for revision hip arthroplasty due to aseptic osteolysis, were randomized into two groups, one received the alendronate for 8 weeks prior to surgery and another received placebo. The pseudo membrane was harvested at the time of surgery and immunohistochemistry and various cytokine expressions were tested in the two groups. In conclusion, the alendronate therapy prior to revis...

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