Oral acetaminophen demonstrates similar analgesic efficacy to IV acetaminophen in TKA and THA

How to Cite

OrthoEvidence. Oral acetaminophen demonstrates similar analgesic efficacy to IV acetaminophen in TKA and THA. ACE Report. 2018;7(5):16. Available from: https://myorthoevidene.com/AceReport/Report/10202

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:N/A

Randomized trial of oral versus intravenous acetaminophen for postoperative pain control

Am J Health Syst Pharm. 2018 Mar 15;75(6):367-375

Contributing Authors: SR Hickman KM Mathieson LM Bradford CD Garman RW Gregg DW Lukens

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Synopsis

515 patients scheduled for total knee or hip arthroplasty were randomized to either oral acetaminophen or intravenous acetaminophen as part of their postoperative analgesia regimen. The primary outcome was opioid use over the first 24 hours after surgery. The main secondary outcome was pain score on a numeric rating scale after 4 and 24 hours. Results demonstrated no significant differences betwee...