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ACE Report #10084
Ace Report Cover Osteoarthritis

Assessing efficacy of an autologous protein solution injection versus saline for knee osteoarthritis

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:2

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

Am J Sports Med. 2018 Jan;46(1):171-180.

Contributing Authors: L Engebretsen R Verdonk E Kon G Filardo S Nehrer

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46 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized in a 2:1 fashion to intraarticular injection of either the Autologous Protein Solution blood product (nSTRIDE APS; Biomet Zimmer) or placebo saline. Patients were assessed for clinical measures and imaging results over a 12-month follow-up. For pain, the WOMAC pain score demonstrated favourable improvement in the A...

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