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RCT
ACE Report #10021
Ace Report Cover Spine

E. coli-derived rhBMP-2 offers similar fusion success to AIBG in posterolateral lumbar fusion


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in posterolateral lumbar fusion: an open, active-controlled, randomized, multicenter trial

Spine J. 2017 Dec;17(12):1866-1874

Contributing Authors: JH Lee HJ Kim KH Koo CK Lee KB Lee H Kim KS Suk JJ Yang JH Cho CJ Hwang J Han JS Yeom BS Chang WD Nam

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Synopsis

100 patients scheduled for posterolateral fusion due to severe spinal stenosis, grade 1 spondylolisthesis, or spondylolysis were randomized to graft material of either Escherichia coli-derived recombinant human bone morphogenetic protein-2 (rhBMP-2) in a hydroxyapatite carrier or an autologous iliac crest bone graft. Patients were assessed primarily for fusion success on CT at 12 and 24 weeks. Sec...

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