High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF
The effectiveness of low-dose and high-dose tranexamic acid in posterior lumbar interbody fusion: a double-blinded, placebo-controlled randomized studyEur Spine J. 2017 Nov;26(11):2851-2857
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72 patients scheduled for posterior lumbar interbody fusion were randomized to either high-dose tranexamic acid, low-dose tranexamic acid, or placebo saline. All patients were treated with an initial bolus prior to incision, followed by continuous infusion for the next 5 hours. Main outcome measures included intraoperative, postoperative, and total blood loss, as well as transfusion rate. Measures...
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