RCTs

Efficacy of PRP vs. Placebo/Control for Knee OA

The graph below summarises the results of the included randomized controlled trials, presenting the number of comparisons that evaluated an outcome at a given time point, and the proportion of comparisons that statistically significantly favoured platelet-rich plasma, indicated no difference between treatments, or statistically significantly favoured placebo/control. To view the individual studies included in each analysis, click on the area of interest on the graph and then review the provided list of studies.
Learn about our approach
OrthoEvidence identified published randomized controlled trials that assessed the use of platelet-rich plasma in the treatment of osteoarthritis through a search of electronic databases, reviewing the reference list of included publications, and suggestions from experts in the field.
The inclusion criteria for published trials were: 1) patients allocated to interventions in a randomized fashion, 2) trials provided a comparison of platelet-rich plasma to placebo/control, and 3) trials evaluated pain, function, stiffness or safety outcomes.
Data relating to clinical outcomes, statistical significance of findings, and product characteristics were extracted from each of the included randomized controlled trials and summarized in the graphics below.
Additional information for each included randomized controlled trial can be found in the corresponding ACE Reports, which can be accessed by clicking on the area of interest on the graph below and then reviewing the provided list of studies. To learn more about the ACE report creation process, click here.

Select an outcome above the table presented below, then view the results by the available patient and product characteristics.
Overall
Leukocyte-Poor
Leukocyte-Rich
Overall
Leukocyte-Poor
Leukocyte-Rich
Overall
Leukocyte-Poor
Leukocyte-Rich
Pain - Overall
Favours PRP
No Difference
Favours Placebo Control