OrthoEvidence identified published randomized controlled trials that assessed the use of
intra-articular hyaluronic acid in the treatment of osteoarthritis through a search of
electronic databases, reviewing the reference list of included publications, and suggestions from
experts in the field.
The inclusion criteria for published trials were: 1) patients allocated to interventions in a randomized
fashion, 2) trials provided a comparison of intra-articular hyaluronic acid to platelet-rich plasma, and 3)
trials evaluated pain, function, or stiffness outcomes.
Data relating to clinical outcomes, statistical significance of findings, and product
characteristics were extracted from each of the included randomized controlled trials and
summarized in the graphics below.
Additional information for each included randomized controlled trial can be found in the
corresponding ACE Reports, which can be accessed by clicking on the area of interest on the graph
below and then reviewing the provided list of studies. To learn more about the ACE report creation
process, click here