Meta-analyses

Hyaluronic Acid vs. Placebo/Control

The table below summaries the results from the meta-analyses. Outcomes are categorized as pain, function and stiffness. Results are shown as an overall analysis or as individual analyses of different patient and product characteristics.
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The results have been categorized as a statistically significant result in favour of intra-articular hyaluronic acid, no difference statistically compared to placebo/control, or a statistically significant result in favour of placebo/control. Values are presented as either a:
  • Mean Difference (MD)
  • Standardized mean difference (SMD)
OrthoEvidence identified published meta-analyses that assessed the use of intra-articular hyaluronic acid in the treatment of osteoarthritis through a systematic search of electronic databases, reviewing the reference list of included publications, and suggestions from experts in the field.
The inclusion criteria for meta-analyses were: 1) inclusion of only randomized controlled trials, 2) provided a comparison of intra-articular hyaluronic acid to placebo/control, and 3) evaluated pain, function, or stiffness outcomes.
Data from each of the included meta-analysis was extracted and summarized in the tables below below regarding effect size, statistical significance, and results by patient & product characteristics.
Additional information for each included meta-analysis can be found in the corresponding ACE Report, which can be accessed by clicking on the trial ID within the table. To learn more about the ACE report creation process, click here.

Select an outcome above the table presented below , then view the results by the available patient and product characteristics.
Overall
Age
Body Mass Index
Cross-linked
Number of Injections
Molecular Weight
Disease Severity
Symptoms Duration
Overall
Age
Body Mass Index
Cross-linked
Disease Severity
Symptoms Duration
Overall
Pain - Overall
Hover over individual results to read a plain language summary of the meta-analysis.
Study Population In favour of IAHA No difference In favour of Placebo